Wednesday, March 11, 2020

New story in Health from Time: 7-Eleven Owner Arrested After Selling ‘Dangerous’ Homemade Sanitizer



The owner of a 7-Eleven in River Vale, New Jersey has been arrested after allegedly making and selling a “dangerous ‘spray sanitizer'” that resulted in apparent burns on children’s skin, authorities said. This comes amid a nationwide shortage of hand sanitizer, as people stock up on cleaning supplies in the face of a coronavirus outbreak.

Read more: Americans Are Stockpiling Cleaning Products Due to COVID-19 Fears. Do They Actually Prevent Coronavirus?

Manisha Bharade, 47, was arrested Tuesday and charged with deceptive business practices and endangering the welfare of a child, according to Bergen County prosecutors.

Police responded to the 7-Eleven in River Vale on Monday night to seize the remaining bottles of an item that was sold as “spray sanitizer,” after social media posts showed three 10-year-old boys and one 11-year-old boy had suffered apparent burns on their arms and legs after using the product.

“While further investigation is underway, our first priority is to make the public aware that they should not use this item if they purchased it at the River Vale 7-Eleven,” Lieutenant John DeVoe said in a statement on Monday. “As far as we know, this issue is limited to the River Vale store at this time. From the information that we received, approximately one dozen of the bottles were sold to customers today.”

Bharade allegedly mixed commercially available foaming sanitizer with water and packaged it for resale. A chemical reaction from the mixture caused the burns, according to Bergen County prosecutors. Bharade could not immediately be reached for comment.

The New Jersey Division of Consumer Affairs has also opened an investigation into the sale of other health and sanitation products at the store in the months since the coronavirus outbreak began in China.

“Let me be perfectly clear: if you try to take advantage of our residents during a public health emergency, we will hold you accountable,” New Jersey Attorney General Gurbir Grewal said in a statement. “Retailers who try to make a quick buck by exploiting others will face civil and criminal consequences.”

As of Wednesday morning, there were more than 1,000 confirmed cases of coronavirus, which causes a disease known as COVID-19, across the United States, including 29 deaths, according to a virus tracker from researchers at Johns Hopkins University.

The Centers for Disease Control and Prevention has recommended that people wash their hands regularly with soap for at least 20 seconds to avoid getting sick. If soap and water are not available, the agency recommends using a hand sanitizer that contains at least 60% alcohol.

New story in Health from Time: The Coronavirus Is Starting to Spread Across Britain. Here’s What to Know



A man in his 80s became the sixth person infected with the new coronavirus to die in the U.K. on March 10, as the country announced 373 cases have been confirmed. COVID-19, the disease caused by the virus, has killed more than 4,300 people and sickened more than 121,000 globally. It has been declared a “Public Health Emergency of International Concern” by the World Health Organization. Here’s what to know about the situation in the U.K., and how the government is responding to the outbreak.

How many COVID-19 cases does the U.K. have now?

According to data from the Johns Hopkins University Center for Systems Science and Engineering on Tuesday, March 10, there have been 382 cases of the disease in the U.K. The majority of cases have been in England, although Wales, Scotland and Northern Ireland have all confirmed multiple cases.

The first cases in the U.K. were confirmed at the end of January. They were reported in the northern city of York, where two Chinese nationals tested positive for the coronavirus on January 29. On March 5, a woman with underlying health conditions became the first person in the U.K. to die from the disease after testing positive for the coronavirus.

March 10 marked the second largest day-on-day increase in the country since the outbreak was first reported. Nadine Dorries, an elected member of parliament and a health minister, confirmed that she had tested positive for coronavirus the same day. After first reporting feeling ill last Friday, the minister carried out her busy schedule and met hundreds of people.

Where in the U.K. has the most cases?

Government figures suggest that London has the highest number of confirmed cases in England, at 91 as of March 10. The city’s financial hub in Canary Wharf was affected last week, as HSBC evacuated a floor of its office tower after an employee tested positive for the virus. Hertfordshire, Devon and Hampshire also have high concentrations of confirmed cases.

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How bad could the U.K.’s coronavirus outbreak get?

As data is still emerging about this new disease, it’s unclear exactly what the impact will be. According to the government’s coronavirus action plan, “in a stretching scenario, it is possible that up to one-fifth of employees may be absent from work during peak weeks.” The government also said it is more likely than not that the U.K. will be significantly affected, as current data indicates that everyone is susceptible to catching the disease.

Professor Francois Balloux, of the University College London Genetics Institute, said on March 10 that the progress of COVID-19 in the U.K. is “so far roughly comparable to the one in northern Italy, but with the epidemic in northern Italy two to three weeks ahead of the situation in the U.K.” On Monday, Italy placed its 60 million residents under lockdown as the number of confirmed cases of coronavirus rose to the highest number of cases and deaths outside of China.

Coronavirus outbreak, government campaign
Matthew Chattle—Barcroft Media via Getty ImagesCoronavirus campaign by the government on billboards in Wood Green, north London

How is the U.K. government preparing?

The U.K. government’s focus has been on containing and delaying the spread of the virus. This involves tracing people who had contact with those diagnosed with COVID-19 and getting them to self-isolate. The BBC reports there are 30 hospitals on stand-by to take patients, and the rest of the NHS has been put on emergency footing. All patients who have flu-like symptoms are now being tested. Last week, a survey found that more than 99% of medics thought that the NHS was not well prepared for the coronavirus outbreak.

A range of other measures, including school closures, restrictions on public transport, stopping big gatherings and using new legal powers to make people stay in quarantine are at the government’s disposal, but these measures have not been taken so far. England’s deputy chief medical officer said that cancelling big outdoor events would not be a decision supported by science. While Dr Jenny Harries said that the virus will not survive long outside and that outdoor events are “relatively safe,” a recent editorial in The Lancet medical journal noted that the situation in China indicates “that quarantine, social distancing and isolation of infected populations can contain the epidemic.”

At a press conference on Monday, Boris Johnson was asked why he hasn’t followed the lead of other European countries by banning mass gatherings. “What’s happening in other countries doesn’t necessarily mirror what’s happening here in the U.K. and that is why we’re following the scientific evidence in the way that we are,” the Prime Minister said. Johnson suggested that elderly and vulnerable people could be asked to stay at home in the near future as the government tries to delay the peak of the outbreak to the summer, when the NHS will be be better able to manage.

After health minister Dorries was diagnosed on Monday, Johnson’s team of advisers said there was no need to test the Prime Minister for the coronavirus, as he had not been in close contact with Dorries and regularly washes his hands, Bloomberg reports. Johnson’s government is reportedly working with a behavioral psychology team to emphasize hand-washing among the British population. So far, Johnson’s response to the virus has been criticized for being more relaxed compared to efforts around the world, including in other parts of Europe.

How could the coronavirus outbreak disrupt daily life in Britain?

The British Medical Association said that primary care physicians (widely called GPs in the U.K.) may have to stop carrying out routine health checks, assessing blood pressure, diabetic control and monitoring long term heart and lung disease, in order to “focus on the sickest patients” amid the outbreak. Dr Richard Vautrey, chair of the BMA’s GP committee, told the BBC that patients with mild health complaints should expect to wait longer to see their GP, and that cases of coronavirus were expected to “rise rapidly and over the coming weeks.”

Reports suggest consumers are panic buying and emptying shelves of everyday items including toilet roll and hand sanitizer amid the outbreak. Some shops have introduced sales restrictions on certain items, including pasta and tinned vegetables.

UK Braces For Rising Incidence Of COVID-19
Getty Images—2020 Matthew HorwoodEmpty shelves in a Cardiff Tesco store on March 9, 2020 in Cardiff, United Kingdom. The retailer has put in place measures to limit the number of purchases of certain items after a recent surge in demand.

How could COVID-19 affect the U.K.’s economy post-Brexit?

Amid the outbreak on March 11, the Bank of England cut U.K. interest rates to the lowest level in the Bank’s 325-year history, from 0.75% to 0.25%. Mark Carney, the outgoing governor of the Bank of England, said that economic damage caused by COVID-19 was as yet unclear, but suggested that the U.K. economy could shrink in the coming months. The U.K. economy failed to grow in January even before the growth of the outbreak in Europe, adding to the case for the emergency cut.

The same day, Chancellor Rishi Sunak delivered the 2020 U.K. budget, opening by saying he expects the coronavirus to have a “significant impact” on the U.K. economy. Sunak also said that the government will give the National Health Service “whatever extra resources our NHS needs to cope with COVID-19,” will also introduce a loan scheme to support small and medium sized businesses, and will extend sick pay for some workers. Overall, he announced a £30 billion ($39 billion) stimulus to support the economy through the outbreak.

Please send any tips, leads, and stories to virus@time.com.

Sami Labs appoints Neeraja Shetty as CEO

During her previous assignments with Sami Labs, Neeraja held the positions of CEO - Formulations between 2002 to 2008 and was the Director & President – Strategy & Business Development from 2011 to 2017. ​

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Health insurance policies adequate to cover coronavirus, no urgency for new products

The Insurance Regulatory and Development Authority of India (IRDAI) recently advised insurance companies to ensure that the affected patients be expeditiously handled and to design products covering the treatment cost for coronavirus.

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Tuesday, March 10, 2020

Now, 5 corona cases confirmed in Maha, Kerala put under lockdown

India’s count of coronavirus cases rose by 18 to 62 with eight testing positive in Kerala, five in Maharashtra, four in Karnataka and one in J&K on Tuesday.

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Coronavirus: India temporarily suspends visas to France, Germany & Spain nationals; issues advisory

India has “strongly advised” its citizens to refrain from travelling to France, Spain and Germany.

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New story in Health from Time: Don’t Blame China. The Next Pandemic Could Come from Anywhere



The northern side of Chatuchak Weekend Market feels a bit like Noah has hit hard times and decided to offload the entire contents of his Ark. In wooden cages, bright-plumed fighting cocks squawk and peck. Around the corner are snakes in plastic takeout containers, prices scrawled on them in sharpie. Hairless squirrel kits snooze in a pile as a meerkat and giant iguana gaze on. A pygmy monkey leaps about with a furious scowl, perhaps indignant at the 30,000 baht ($950) price tag fixed to his enclosure. Across the narrow alleyway, a lynx prowls restlessly within its cage. “He’s 250,000 baht [$7,900],” says the heavily tattooed market trader. “This one is only five years old, so will double in size. He’s a male but I have a female too.”

Given the sheer number and variety of exotic creatures on sale at Chatuchak Weekend Market, you’d think it was hidden in some jungle border town between failed states. In fact, it’s directly in the middle of the sprawling Thai capital of Bangkok. Chatuchak ranks number three on TripAdvisor’s list of top tourist attractions in the city, owing to its 15,000 stalls that hawk everything from bolts of silk to golden Buddha amulets and wooden furniture. Bangkok is already the world’s most visited city, and third most globally connected place in Asia, with an estimated 22.7 million international visitors in 2019. This is evidenced by the perspiring tourists — more than 60,000 each weekend day, according to estimates — that throng Chatuchak’s green-roofed labyrinth. They shop for spices, T-shirts and trinkets, but it’s easy to wander into the euphemistically named “pet” section.

From Bangkok, the holidaymakers jet off home—to a world still reeling from the COVID-19 virus outbreak that began in a live animal market in China’s central city of Wuhan and has since spread globally, sickening nearly 118,00 and killing almost 4,300 people in what the WHO has now declared a “global health emergency.” The outbreak, a novel coronavirus which experts believed jumped from an unidentified animal to humans, has shone a spotlight on China’s consumption of wild animals and penchant for “warm meat”—the term for animals that are transported live to markets and slaughtered to order.

Thailand-wildlife-crime, by Claire Trusc
AFP/Getty Images This handout photo shows a Royal Thai police officer holding a slow loris during a raid with wild life rescuer at the Chatuchak market in Bangkok on March 22, 2008.

Severe acute respiratory syndrome (SARS) emerged 17 years earlier from a market in China’s Guangdong province—on that occasion via civet cats—and the Chinese combination of live, wild animals, poorly regulated animal husbandry and unsanitary butchery is “a perfect storm for viruses to emerge,” says Kevin Olival, an evolutionary biologist with NGO EcoHealth Alliance, who has been researching emerging pandemics for over a decade. China’s government has taken note and introduced new regulations on the rearing and sale of exotic animals. (Though, given lax enforcement of previous curbs after SARS, only time will tell whether they hold up.)

Still, the “pet” section of Chatuchak market in Thailand is just one example, among many scattered around the region, that demonstrate the potential health risks are not just Chinese. Across Asia, lax regulations and poor enforcement can be readily exploited. In Chatuchak, traders say their animals were acquired lawfully, and many proffer documentation to prove it. But forgeries are easy to obtain and difficult to spot, says Steven Galster, founder of Bangkok-based wildlife conservation NGO Freeland. It’s also tricky to prove whether papers truly correspond to specific animals.

According to Galster, who conducts regular inspections and raids at Chatuchak alongside Thai police, unscrupulous traders “launder” poached exotic animals alongside domestically farmed ones. Farms also like adding wild creatures to their breeding stock to widen the genetic pool. Galster says the same supply chains that fed Wuhan also provide animals other “sleeping timebomb” markets around the region. “They are warm, crowded and just perfect for another disaster,” says Galster. “And we know it’s going to happen at some point.”

According to Pongsakorn Kwanmuang, spokesman for the Bangkok Metropolitan Administration (BMA), the exotic animal section of Chatuchak operates in a legal gray zone since it sits on land owned by the State Railway of Thailand. As such, and despite the absence of any discernible divide with the rest of the 27-acre market, “The BMA has no authority over such property apart from those prescribed by the related local laws and regulations, which do not include the monitoring and policing the sale of exotic wildlife,” says Pongsakorn, adding that the BMA regularly patrols, cleans and disinfects the sections of the market that fall under its jurisdiction. The State Railway of Thailand did not respond to requests for comment.

Huanan Seafood Wholesale Market
Getty Images An employee walks past the closed Huanan Seafood Wholesale Market, which has been linked to cases of coronavirus, on Jan. 17, 2020 in Wuhan, Hubei province, China. Local authorities have confirmed that a second person in the city has died of a pneumonia-like virus since the outbreak started in December.

Another big risk is mixing live, wild animals with intensively reared livestock, as was done at Wuhan’s now-shuttered Huanan Seafood Wholesale Market, where COVID-19 is thought to have originated. Raising pigs, cows and chickens en masse makes it difficult to spot when one or two animals get sick, meaning infections can spread quickly and silently across a herd or flock. Experts say that demand for “warm meat” is one of the main reasons why diseases such as avian flu and African Swine Fever have proven so tricky to stamp out, given the huge movements of live animals all around and between countries.

In addition, studies suggest overuse of prophylactic antibiotics—a common practice in modern intensive farming meant to prevent rather than treat disease—can suppress animals’ immune systems, making them more susceptible to viral infections. In many of Asia’s live animal markets, blood, feces and other bodily secretions can mix freely. Melissa Nolan, an infectious disease expert and professor at the University of South Carolina, says she once observed a slaughter market in the Philippines where butchers “stood ankle-deep in blood with just flip flops on.” Under such circumstances, she adds, “There’s so much potential for multiple different pathogens from a blood-borne and viral transmission perspective.”

Such markets are common all over Asia, from Colombo to Kuala Lumpur and beyond. Live fish splash water from plastic tubs over neighboring live turtles and shellfish. Countertops are red with blood and guts brought forth by razor-sharp filleting knives. But while the presence of butchery at such markets adds another element of risk, pet markets like the one at Chatuchak are also problematic. Chaotic, cramped conditions weaken animals’ immune systems, producing an environment where viruses can mix, swap bits of genetic code and leap between species. In this way, they can present “as much of a risk factor” as markets where butchery takes place, according to Olival.

Housing together many different kinds of animals—wild, domesticated and many not native to that particular locale—gives more opportunities for viruses to jump between species. SARS, for example, actually originated in bats—which tend to be riddled with pathogens—then jumped to civet cats, which acted as the “amplifying host” before making the jump to humans.

Such zoonotic pathogens have caused nearly every pandemic in human history, including the 1918 flu pandemic, which killed between 50 and 100 million people worldwide and began in birds. Then there are HIV, Nipah, West Nile, Ebola, and so on. Without closing down markets that host wild creatures, whether for consumption or as pets, Nolan says she’s “very confident” that the next serious pandemic is just around the corner.

But even closing those markets would not be fool-proof. After all, every square meter of the planet hosts some 800 million viruses. Middle East respiratory syndrome (MERS) continues to crop up in the Middle East due to human contact with camels. Ending the consumption of unpasteurized camel’s milk would go a long way toward stemming the outbreaks, though only the culling of all 1.5 million camels on the Arabian peninsula would permanently solve the issue, says Prof. Michael Osterholm, an epidemiologist at the University of Minnesota. “And that just isn’t going to happen.”

Ultimately, problems emerge wherever humans come into close contact with unfamiliar animal populations, which is fed by the destruction of natural habitats. It is believed the West African Ebola outbreak emerged when a child unwittingly ate something contaminated by the droppings of bats that nested in his village, possibly due to nearby deforestation. Outbreaks of Nipah virus—which has a fatality rate of up to 75%—are increasingly breaking out near date palm plantations because carrier bats love to sit in the trees. Lassa fever spreads via infected rats.

The next pandemic could even emerge in the U.S. While China is well known as the world’s top consumer of trafficked wildlife, less reported is the fact the U.S. is number two. Outside Denver, the National Wildlife Property Repository, run by the U.S. Fish and Wildlife Service, is a 22,000 square foot warehouse teeming with ivory, tiger pelts and stuffed reptiles. But the service also deals with a large quantity of smuggled live animals. Indeed, a 2003 outbreak of monkeypox across six U.S. states was traced back to an illegal shipment of pouch rats and other rodents from Ghana to Texas for the exotic pet trade—just like the one carried on at Chatuchak.

So while banning the sale of wildlife, reducing the mass transportation of live animals, and ensuring high standards of butchery hygiene can all mitigate the possibility of another pandemic, there will always be a risk as long as people and animals mix. “We can’t get rid of the bats or abolish farms,” says Osterholm. “So the only choice we have is to develop vaccines that can protect people.”

COVID-19: Anti-HIV drugs administered on Italian couple at Jaipur hospital

"The female has tested negative now and her condition has improved while 69-year-old male is still positive and on non-invasive ventilation (NIV) support.

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New story in Health from Time: States Need Medical Supplies to Fight Coronavirus. Can the National Stockpile Keep Up With Demand?



The outbreak of the coronavirus in the United States is the latest test for the federally managed Strategic National Stockpile (SNS), a secretive stash of medical supplies and equipment that the government has stored in case of emergencies.

As the virus spreads throughout the United States — there are now more than 700 confirmed cases and nearly 30 people have died — the way that lifesaving supplies like masks and respirators are doled out from the nation’s repository to states with high case loads will mark a critical proving ground for the efficacy of the Trump administration’s response, which has been criticized as insufficient and short-sighted to deal with a public health crisis of this magnitude.

The Department of Health and Human Services (HHS), which manages the SNS, has already made clear that the stockpile may not be able to meet the demands of the growing outbreak. And it is already being tested, as at least two states scrambling to contain the spreading coronavirus have requested shipments of emergency supplies.

Last week, Massachusetts requested personal protective equipment from the stockpile including face masks, gowns, gloves and eye protection, according to Monica Bharel, Commissioner of the Massachusetts Department of Public Health. Bharel said that request had been approved on March 10. “Those supplies are on the way,” she said at a press conference that day. “At this time, our health care system has enough, but we need those supplies to be able to continue the work we’re doing.” Massachusetts has more than 90 presumptive or confirmed cases of the coronavirus as of March 10.

On Feb. 29, Washington State, which has recorded more cases than other state so far, also submitted a request for hundreds of thousands of surgical masks, N-95 respirators, and other supplies like latex gloves and disposable gowns, according to a copy of the request shared with TIME. Within 24 hours, Washington was notified that it would receive less than half of its request.

“We have a good working relationship with HHS and clearly communicated to them the need for additional PPE (personal protective equipment),” says Casey Katims, director of federal and inter-state affairs for the Washington State governor’s office. “Members of our congressional delegation also communicated the importance of delivering the remainder of the request to the administration, and… we communicated about it with the Vice President’s office.” On March 2, after Washington continued talking with HHS and the Vice President’s office about the need for supplies, the Strategic National Stockpile agreed to fulfill the remainder of the request, says Katims.

But as the worst-hit state, the need has continued to grow. And this week, Washington submitted another request for additional materials. (Washington has more than 160 confirmed cases and more than 20 deaths from the virus as of March 10.)

“ASPR has received requests from multiple entities and is obtaining additional information regarding their intended use of the requested personal PPE,” Stephanie Bialek, Stockpile Communication Services Section Chief at HHS, tells TIME in an email when asked about the requests from Washington and Massachusetts. “Our goal is to prioritize the use of stockpiled PPE for the protection of health and medical personnel.” She did not elaborate on what entities had made the requests, or for what.

The Strategic National Stockpile was established in 1999, initially to respond to potential bioterrorism attacks. Since then, its mission has expanded to other emergencies, and it has deployed pharmaceuticals and medical supplies after the 2001 World Trade Center and Anthrax attacks, 2005’s Hurricane Katrina, and 2017’s Hurricanes Harvey, Irma and Maria, among other crises. Over the past 20 years, it has grown to hold a $7 billion inventory and essentially has become “the largest pharmacy in the world,” as Ali Khan, who used to oversee the SNS and is now the Dean of the College of Public Health at University of Nebraska Medical Center, puts it.

HHS Secretary Alex Azar and Assistant Secretary for Preparedness and Response Robert Kadlec, who is responsible for the stockpile, have both testified before Congress in recent days that it has only a small fraction of the supplies that could be needed as the virus spreads.

HHS estimates the U.S. could need up to 3.5 billion N95 respirator masks, the mask that the Centers for Disease Control and Prevention (CDC) recommends health care workers use when treating patients with the coronavirus, over a year in a pandemic. But the stockpile currently holds approximately 12 million N95 respirator masks and 30 million surgical face masks, HHS officials say.

“We’re actively working on that,” Kadlec told the Senate Committee on Health, Education, Labor, and Pensions on March 3. HHS plans to purchase 500 million N95 respirators over the next 18 months for the Strategic National Stockpile to help shore up its reserves.

The stockpile is designed to supplement states’ own supplies and help fill in gaps, and it will ultimately be up to Kadlec to decide how to triage requests from states if the system becomes overwhelmed. But his office’s management of the complex system is relatively new: two years ago, the Trump administration moved oversight of the stockpile from the CDC to the Assistant Secretary of Preparedness and Response, so this will be the first major test of the new chain of command. In 2018, former acting White House Chief of Staff Mick Mulvaney wrote that the shift would “streamline operational decisions during responses to public health and other emergencies and improve responsiveness,” the Washington Post reported. Other officials, however, had raised concerns that the shift would disrupt a proven system.

Whoever is in charge, running the stockpile is a critical job. Khan explains the importance of its oversight with a hypothetical: What if Washington State had requested every single N95 mask the government has? “These are some of the risk based, evidence-based, political-based decisions that the director of the SNS and [his] boss will have to factor in,” says Khan, so they can decide, “OK, this is what we can give to different communities over time.”

New story in Health from Time: The Tokyo Olympics Are on for Now — But the Clock Is Ticking



(TOKYO) — The tentacles of canceling the Tokyo Olympics — or postponing or staging it in empty venues — would reach into every corner of the globe, much like the spreading virus that now imperils the opening ceremony on July 24.

The International Olympic Committee and local organizers say the games are on, but the clock is ticking.

The fate of the Tokyo Games touches 11,000 Olympic and 4,400 Paralympic athletes, coaches and sports officials, local organizers, the Japanese government and national morale, international broadcasters, fans and world sponsors. Add to this hotels, airlines and taxi drivers — and even 80,000 unpaid volunteers who will miss a once-in-a-lifetime opportunity.

“I’ve heard things about possibly the Olympics being canceled, and I think that would stink,” J’den Cox, a two-time world champion wrestler and an Olympic bronze medalist in Rio de Janeiro, told The Associated Press. “It would probably break everybody’s heart if that were to happen.”

The Olympic brand could be damaged, although the Switzerland-based International Olympic Committee may be among the least affected parties financially if the games are called off. The IOC has been resolute in its message, although it has a several-month window to decide.

“Hard to imagine this will be defined by the end of May, but it could be,” Dr. Ali Khan. an epidemiologist and dean of the College of Public Health at the University of Nebraska, told the AP in an email. “Regardless, numerous sick athletes could not lead to a very interesting games.

“From what we know from numerous other mass-gathering events including sporting events, it is very easy to spread diseases worldwide from such events — from meningitis to Zika,” Khan added. “Besides welcoming athletes and spectators with their tiny microbes, there is and may be ongoing disease in Japan.”

Kazuhiro Tateda, an expert on infectious diseases and a member of a Japanese government panel, said the virus may not die out quickly.

“Unlike the flu that disappears with warmer weather, the response to the new coronavirus, I think, will have to continue for half a year or a year,” Tateda told Japanese broadcaster NHK on Tuesday.

The IOC has ample financial safeguards against cancellation, which has happened only in wartime since the modern Olympics began in 1896. Its latest annual report shows it has almost $2 billion in reserve that could cover running costs until the 2022 Winter Olympics in Beijing.

The IOC’s annual reports show it paid almost $14.4 million in an insurance premium to protect against canceling the 2016 Rio Olympics and $12.8 million for a policy to cover the 2018 Winter Olympics in Pyeongchang, South Korea.

IOC President Thomas Bach was asked last week after an executive board meeting if the insurance premium has risen to as much as $20 million for a Tokyo policy.

“I don’t know,” he replied. “It wasn’t discussed at this EB.”

Wolfgang Maennig, an Olympic rowing gold medalist who teaches sports economics at Hamburg University, said the losses will be shared.

“Insurance companies will have to pay a large amount of the losses of the IOC,” Maennig said in an email to the AP. “The rest will have to be borne by the IOC.”

The IOC controls the Olympics and has wide latitude to act. Its protection is spelled out in the 81-page Host City Contract, signed in 2013 with the city of Tokyo and the Japanese Olympic Committee.

The preamble to the contact states: “the Olympic Games are the exclusive property of the IOC which owns all rights … to their organization, staging, exploitation, broadcasting, recording, representation, reproduction … whether now existing or developed in the future, throughout the world in perpetuity.”

The contract also specifies that the IOC can terminate and withdraw from the city because of a “state of war, civil disorder, or boycott … or if the IOC has reasonable grounds to believe, in its sole discretion, that the safety of participants in the games would be seriously threatened or jeopardized for any reason whatsoever.”

Victor Matheson, a sports economist at the College of the Holy Cross in Worcester, Massachusetts, said athletes are the most vulnerable. The Olympics feature 33 sports, and many of the smaller ones have a limited following until games time.

“For athletes, their career length isn’t long and in many sports success in the Olympics is your one shot at a financial return,” Matheson told the AP.

Matheson said losses by hotels and other service businesses are unlikely to be insured. The billions on government spending on venues looks like a risky investment. The loss of the Olympics would negate the difficult-to-calculate goodwill that Japan and Tokyo might have won.

An Irish bookmaker is showing odds leaning slightly toward the Olympics not going forward. Odds are 4-6 it will not open on July 24 in Tokyo, and even that it will.

Tokyo is officially spending $12.6 billion to organize the Olympics, although a national government audit office says it’s at least twice that much. The local organizing committee budget of $5.6 billion is private money, with the rest coming from Japanese taxpayers. About $1 billion in the local operating budget is to come from ticket sales, which would be lost if the games go ahead without fans in empty stadiums.

“Some combination of the IOC, the broadcasters, and the insurers will lose big,” Matheson said. “That loss is coming out of someone’s pocket depending on how all of the contracts are written.”

Andrew Zimbalist, who teaches economics at Smith College in Northampton, Massachusetts, said some of the venues, such as the $1.43 billion national stadium, would have “enduring value.”

“But virtually none of it would have made the list of the priority public investments,” he said in an email to the AP, adding that if the games were canceled, much of the investment would be “wasted.”

The IOC has said repeatedly the games will go on, and says it relies on advice from the World Health Organization. The WHO, the U.N. health agency, has so far resisted describing the crisis as a “pandemic,” which could force the IOC’s hand. But many experts say that threshold has already been met.

More than 113,000 people have been infected worldwide from the virus, far more than those sickened by SARS, MERS or Ebola in recent years. More than 4,000 have died.

For most people, the new coronavirus causes only mild or moderate symptoms. For some, especially older adults and people with existing health problems, it can cause more severe illness, including pneumonia.

The vast majority of people recover from the new virus. According to the WHO, people with mild illness recover in about two weeks. Those with more severe illness may take three to six weeks to recover. In mainland China, where the virus first exploded, more than 80,000 people have been diagnosed and more than 63,000 so far have recovered.

About 73% of the IOC’s income of $5.7 billion in the latest four-year Olympic cycle (2013-2016) was from selling broadcast rights. The U.S. network NBC makes up at least half of the broadcast payments. Another 18% of IOC income is from sponsorships.

NBC parent company Comcast said that because of insurance and the way contracts are written, NBC won’t suffer losses if the Olympics are canceled. But Comcast CEO Brian Roberts said the company would miss out on ad-driven profits, which were $250 million for the 2016 Rio Olympics. The ad profits for 2020 are expected to be larger.

NBC signed a deal to pay $4.38 billion for four Olympics — 2014 through 2020. It has a new agreement to pay $7.75 billion for the following six Olympics — 2022 through 2032.

Christopher Chase, an attorney based in New York who specializes in sports, intellectual property and media, said sponsors and broadcasters were unlikely to sue for breach of contracts if the games are not held, or the conditions were changed.

Chase, a partner in the law firm Frankfurt Kurnit, said many such contracts would have “force majeure” or “changed circumstances” clauses that spell out unforeseeable conditions that keep a contract from being fulfilled; these act as a defense for non-performance by either party, but in this case, more likely the event producer.

The IOC, much like other large properties such as FIFA and the NFL, “the last thing they want to do is refund fees or lower the cost of what the sponsorship is,” Chase told the AP. “The last thing they want to do is give any money back or charge less. So typically what they try to do is negotiate some kind of make-good or substitute benefits.”

Over and above the IOC’s major sponsorship deals, local sponsors have paid just over $3 billion to the organizing committee.

“Any party that has already spent money to put people on the ground, flights and hotel rooms and all those types of things, are most likely going to lose out on that,” Chase said. “The sponsorship fee may be the least of their concerns.”

___

Dunbar reported from Lausanne, Switzerland; AP Medical Writer Maria Cheng in London, and AP Sports Writer Eric Olson in Omaha, Nebraska, contributed to this report.

New story in Health from Time: Coronavirus Drug and Vaccine Studies Are Recruiting Their First Volunteers



As COVID-19 continues to spread both around the world and in the U.S., two separate efforts to find a medical solution to the virus are moving forward. At the University of Nebraska, the first patients have volunteered to test an experimental drug to treat COVID-19. And at Kaiser Permanente Washington Health Research Institute, researchers have begun recruiting people to test a possible vaccine.

A number of U.S. passengers aboard the Diamond Princess cruise ship were brought to Nebraska for quarantine; two of these passengers have agreed to participate in a trial for remdesivir, an antiviral drug originally developed for Ebola, but which showed encouraging results in animals in fighting SARS and MERS, two other illnesses caused by coronaviruses.

The drug is designed to treat infections that are moderate to severe, and is targeted to those with the most intensive symptoms. In order to qualify for the remdesivir study, run by the National Institute of Allergy and Infectious Diseases (NIAID), patients must test positive for COVID-19 and have pneumonia. Of the more than two dozen people diagnosed with COVID-19 from the cruise ship who were brought to Nebraska for quarantine, four required hospitalization and two developed pneumonia. Those two patients were asked if they wanted to volunteer for the study, and both agreed, says Dr. Andre Kalil, professor of medicine in the division of infectious disease at University of Nebraska Medical Center.

The study will eventually include 400 patients; initial results won’t be analyzed until the first 100 have completed treatment. Given the relatively low rate of moderately to severely affected patients in the US at this point, Kalil says that NIAID plans to collaborate with health officials from other countries with higher case volumes, including Korea, Japan and Italy. For now, the trial will stay open for three years in order to recruit the needed number of patients.

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This study, says Kalil, is also designed to be more flexible than most drug trials. “This is not just a remdesivir trial,” he says. “It will test as many [COVID-19] therapies as possible, and remdesivir is just the first. Let’s say a couple of months from now, we realize that remdesivir is a good drug, that it works better than placebo…. Then patients receiving the placebo would be offered the drug and we would move on to test another drug. If remdesivir turns out not to be effective, then we would remove it from the study and bring another drug to test against placebo. It’s a dynamic, fast way to run a randomized trial.” The design is a way to accelerate testing of antiviral drugs against COVID-19, since infections are on-going and there is no treatment yet.

Meanwhile, other labs are working on developing vaccines that would provide some protection against the virus in the first place. The vaccine study that is furthest along (and which is also overseen by NIAID) is currently recruiting its first participants at Kaiser Permanente Washington Health Research Institute. Unlike the remdesivir trial, this study will enroll healthy volunteers. Dr. Lisa Jackson, lead investigator on the study, says 45 healthy people will be recruited to test three different doses of the vaccine.

Kaiser is currently getting thousands of daily online requests from people interested in participating. Researchers are contacting the volunteers by phone to assess their eligibility for the study. Once the participants are chosen, they will be given one of the three vaccine doses being tested. The scientists will track patients’ immune responses after that injection, and then give each patient a second injection (of the same dosage). The goal is to figure out which dosage is most effective, and whether one or two shots of that dosage is needed.

They’ll be looking for levels of antibodies that the body’s immune system produces against the so-called spike protein, one of the proteins that stud the surface of the SARS-CoV-2 virus responsible for causing COVID-19. Scientists will analyze antibody levels in the participants a year after their second vaccination, so results won’t be available for at least 12 to 18 months, says NIAID director Dr. Anthony Fauci. Given that coronaviruses like the one behind COVID-19 seem to be appearing more frequently, however, having a vaccine against this particular virus could be useful in creating future coronavirus vaccines as well.

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Monday, March 9, 2020

Italy imposes nationwide restrictions to contain new virus

Italian Premier Giuseppe Conte says travel restrictions are being imposed nationwide to try to stop the spread of the spread of the new coronavirus.

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Coronavirus latest updates: Threat pandemic now 'very real', says WHO

The WHO warned on Monday there was now a "very real" threat that the global outbreak of the coronavirus will become a pandemic, but stressed the virus could still be controlled.

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New story in Health from Time: Italy Extends Travel Restrictions to the Entire Country to Try and Contain Spread of COVID-19



(MILAN) — Italian Premier Giuseppe Conte says he is extending restrictions on travel from the north to entire country to try to stop the spread of coronavirus.

Conte said Monday night that a new government decree will require all people in Italy to demonstrate a need to work, health conditions or other limited reasons to travel outside the areas where they live.

“There won’t be just a red zone,” Conte told reporters referring to a lockdown of areas in northern Italy instituted over the weekend.

“There will be Italy” as a protected area, he said.

THIS IS A BREAKING NEWS UPDATE. AP’s earlier story follows below.

MILAN — Confusion reigned in northern Italy over who could go where and under what circumstances Monday, the first business day since the government locked down a vast area with more than one-quarter of the Italian population in a desperate attempt to contain the country’s coronavirus epidemic.

Skyrocketing infections that cemented Italy as a global virus hot spot and superficial compliance with earlier restrictions covering 11 towns led the government to extend its quarantine order to encompass the entire Lombardy region and 14 provinces in the Piemonte, Veneto and Emilia Romagna regions.

Streets in Milan, Italy’s financial hub and the main city in Lombardy, were unseasonably quiet. Check points were set up at the city’s main train station to screen travelers. People at Milan Central Station were being required to sign a police form, self-certifying they were traveling either for ‘’proven work needs,’’ situations of necessity, health reasons or to return to their homes.

‘’Until a few days ago, the thinking was the alarm would pass in some weeks, we just need to follow the rules. Now, we need to explain to citizens that the situation is very, very serious, our hospitals are at the point of collapse,’’ the mayor of the city of Bergamo, Giorgio Gori, told RAI state television.

People circulating inside the city and also in the provinces beyond were subjected to spot checks to ensure they had valid reasons for being out. Violators risked up to three months jail or fines of 206 euros ($225)

The message from authorities was an increasingly blunt ‘’Stay at home.’’

Italy registered 1,807 more confirmed cases as of Monday evening, for a national total of 9,172. With the latest numbers, Italy again overtook South Korea as the country with the most cases outside China. The number of dead in Italy also increased by 97 to 463.

Italian Premier Giuseppe Conte signed a decree early Sunday attempting to lock down 16 million people in Italy’s prosperous north – more than a quarter of Italy’s population — for nearly a month to halt the virus’ relentless march across Europe. The extraordinary measures, which also apply to the city of Venice, will be in place until April 3.

Under the new decree, casual errands are out. The time-honored Italian tradition of an espresso at the corner cafe – gone. Customers now are required to take tables, if possible, the one furthest from the bar. The evening aperitif is also frowned upon; bars close at 6 p.m. Even going to the grocery store is a major expedition.

The regions affected by the decree are among the most productive in Italy. Industry leaders worry about a perception being created abroad that all business was shut down and commercial deliveries of exports can’t be made.

The civil protection agency has emphasized that commercial freight was not affected by the crackdown. But that does not address what happens to drivers who leave the containment area. In theory, they would be subject to 14-day quarantines once they return from trips outside he red zones.

For travelers and commuters, procedures at the main train station have been tightened significantly since the early Sunday morning decree. Now, pairs of police officers in masks backed by pairs of masked armed soldiers check tickets and documents of people arriving and departing.

Patrizia Peluso arrived at the station Monday afternoon from a five-day holiday with her two children in Lapland, Finland. They had to reroute their return flight through Rome after airlines canceled flights to Milan. They grabbed a Naples-Turin train in Rome, connecting two cities not subject to the quanrantine, and were among the few passengers to get off in Milan.

Before letting them pass the gates, soldiers confirmed their residence in Milan and asked their reason for traveling.

‘’I explained we were away on holiday and I have to return to work. If not, I wouldn’t have come back at all,’’ Peluso said.

The first thing she has to do when she gets home: buy groceries.

‘’We have nothing to eat at home. But I hear you have to wait in lines to get into stores,’’ she said. ‘’I hope that everything goes well.’’

____

Barry reported from Soave, Italy.

New story in Health from Time: It Takes About 5 Days for Sick People to Show Coronavirus Symptoms, New Study Says



Questions about coronavirus—how it behaves, who it strikes, and how bad it can get—are spreading almost as fast as the virus itself. Among the most important questions to answer is how long it takes people who are infected by SARS-CoV-2, the virus that causes COVID-19, to show symptoms. Understanding that timeline, known as an incubation period, is crucial to developing effective disease containment and prevention measures.

A new study, published Monday in the Annals of Internal Medicine, offers a new estimate that is largely in keeping with other early studies of the outbreak. The coronavirus’ median incubation period, the new paper says, appears to be about five days, with the vast majority of people developing symptoms within 12 days.

Incubation numbers will “inevitably be refined as we get more information,” says study co-author Justin Lessler, an associate professor of infectious disease epidemiology at the Johns Hopkins Bloomberg School of Public Health, but having early insights is “important for thinking about controls such as quarantine and active monitoring.”

The U.S. Centers for Disease Control and Prevention has been isolating individuals suspected or confirmed to have COVID-19 for 14 days, working off the assumption that the disease’s average incubation period is roughly a week long—and thus, that almost everyone infected by the virus will show symptoms within a 14-day period.

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While there have been reports of incubation periods longer than 14 days, the new study estimates that about 1% of every 10,000 patients would develop symptoms after being released from a two-week monitoring period. At this point in the outbreak, when there’s no longer a possibility of entirely stopping the spread of COVID-19 within the U.S., Lessler says public-health officials may have to live with that risk.

Now that the virus is out there in more places in the U.S., maybe just some risk mitigation and slowing things down is a better strategy” than making quarantine practices even more aggressive, Lessler says. “It’s not like quarantine doesn’t have costs, particularly if it’s a health care worker.”

Lessler and his colleagues based their estimates on 181 confirmed COVID-19 cases reported by media outlets and public-health groups between Jan. 4 and Feb. 24., 2020. Most cases were among people who had traveled to Wuhan, China, where the outbreak originated, and determining exactly when each person became ill required some educated guesswork. Whenever possible, researchers relied on a specific sequence of events—a particular interaction or activity that may have led to infection—to calculate the delay between exposure and symptom onset.

Lessler emphasizes that it’s early days for crunching data about the outbreak—especially in the U.S., where large-scale testing is only just beginning. But as more data about incubation period, mortality rates and other facets of the outbreak accumulate, doctors will have an increasingly solid idea of what they’re up against.

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